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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50144841
Substrate
n/a
Meas. Tech.
ChEMBL_331169 (CHEMBL854096)
Ki
2.3±n/a nM
Citation
 Adams, DR; Bentley, JM; Benwell, KR; Bickerdike, MJ; Bodkin, CD; Cliffe, IA; Dourish, CT; George, AR; Kennett, GA; Knight, AR; Malcolm, CS; Mansell, HL; Misra, A; Quirk, K; Roffey, JR; Vickers, SP Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett 16:677-80 (2005) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-2C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50144841
Synonyms:
(S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-amine | (S)-2-(6-Chloro-5-fluoro-indol-1-yl)-1-methyl-ethylamine | CHEMBL76781 | Ro-60-0175 | Ro-600175
Type:
Small organic molecule
Emp. Form.:
C11H12ClFN2
Mol. Mass.:
226.678
SMILES:
C[C@H](N)Cn1ccc2cc(F)c(Cl)cc12
Structure:
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