Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50176421
Substrate
n/a
Meas. Tech.
ChEMBL_332950 (CHEMBL854080)
IC50
380±n/a nM
Citation
Debenham, JS; Madsen-Duggan, CB; Walsh, TF; Wang, J; Tong, X; Doss, GA; Lao, J; Fong, TM; Schaeffer, MT; Xiao, JC; Huang, CR; Shen, CP; Feng, Y; Marsh, DJ; Stribling, DS; Shearman, LP; Strack, AM; MacIntyre, DE; Van der Ploeg, LH; Goulet, MT Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists. Bioorg Med Chem Lett 16:681-5 (2005) [PubMed] Article
More Info.:
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
Inhibitor
Name:
BDBM50176421
Synonyms:
CHEMBL204391 | N-(6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)acetamide
Type:
Small organic molecule
Emp. Form.:
C23H16Cl3N3O2
Mol. Mass.:
472.751
SMILES:
CC(=O)Nc1cc(=O)n(C)c2nc(-c3ccc(Cl)cc3Cl)c(cc12)-c1ccc(Cl)cc1