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Target
Amyloid-beta precursor protein
Ligand
BDBM50176895
Substrate
n/a
Meas. Tech.
ChEMBL_430882 (CHEMBL913951)
Ki
72.5±n/a nM
Citation
 Ono, M; Yoshida, N; Ishibashi, K; Haratake, M; Arano, Y; Mori, H; Nakayama, M Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain. J Med Chem 48:7253-60 (2005) [PubMed]  Article 
Target
Name:
Amyloid-beta precursor protein
Synonyms:
A4_HUMAN | APP | A4 | AD1 | Cerebral vascular amyloid peptide | Amyloid intracellular domain 59 | P3(42) | PN-II | AICD-50 | PreA4 | Amyloid intracellular domain 57 | S-APP-alpha | P3(40) | Amyloid beta Protein | Gamma Secretase | S-APP-beta | Soluble APP-beta | Alzheimer disease amyloid protein | Gamma-CTF(59) | Gamma-CTF(57) | Protease nexin-II | Amyloid intracellular domain 50 | Beta amyloid A4 protein | C31 | AID(59) | Gamma-CTF(50) | C99 | AID(57) | Amyloid beta A4 protein | Gamma-secretase C-terminal fragment 50 | Amyloid beta protein (sAPPbeta) | Beta-amyloid protein 42 | Gamma-secretase C-terminal fragment 57 | Gamma-secretase C-terminal fragment 59 | Beta-amyloid protein 40 | Soluble APP-alpha | AICD-57 | Gamma-secretase | Amyloid -protein (A 42) | Amyloid protein (Abeta42b) | Beta-APP42 | APPI | Beta-APP40 | Amyloid beta protein Abeta(1-42) | beta-Amyloid Precursor Protein (APP) | AID(50) | CVAP | AICD-59 | ABPP | C83
Type:
Single-pass type I membrane protein
Mol. Mass.:
86890.41
Organism:
Human
Description:
P05067
Residue:
770
Sequence:
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
  
Inhibitor
Name:
BDBM50176895
Synonyms:
6-iodo-4'-hydroxyflavone | CHEMBL388844
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: