Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50177309
Substrate
n/a
Meas. Tech.
ChEMBL_334365 (CHEMBL858944)
EC50
>10000±n/a nM
Citation
 Gao, ZG; Joshi, BV; Klutz, AM; Kim, SK; Lee, HW; Kim, HO; Jeong, LS; Jacobson, KA Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety. Bioorg Med Chem Lett 16:596-601 (2005) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
ADENOSINE A2B | Adenosine receptor A2B (A2B) | AA2BR_HUMAN | ADORA2B | Adenosine receptors; A2a & A2b | Adenosine receptors A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Human
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50177309
Synonyms:
(2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-2-chloro-9H-purin-9-yl)-3,4-dihydroxy-N,N-dimethyl-tetrahydrothiophene-2-carboxamide | (2S,3S,4R,5R)-5-[2-chloro-6-(3-iodo-benzylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-thiophene-2-carboxylic aciddimethylamide | CHEMBL436485
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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