Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50177564
Substrate
n/a
Meas. Tech.
ChEMBL_349444 (CHEMBL865696)
Ki
5.8±n/a nM
Citation
 Shi, Q; Ornstein, PL; Briner, K; Richardson, TI; Arnold, MB; Backer, RT; Buckmaster, JL; Canada, EJ; Doecke, CW; Hertel, LW; Honigschmidt, N; Hsiung, HM; Husain, S; Kuklish, SL; Martinelli, MJ; Mullaney, JT; O'Brien, TP; Reinhard, MR; Rothhaar, R; Shah, J; Wu, Z; Xie, C; Zgombick, JM; Fisher, MJ Synthesis and structure-activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor. Bioorg Med Chem Lett 16:2341-6 (2006) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50177564
Synonyms:
CHEMBL380540 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(diethylamino)-1-(2-fluorophenyl)ethyl)piperazin-1-yl)-1-oxopropan-2-yl)-1,1-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C37H47ClFN5O2
Mol. Mass.:
648.253
SMILES:
CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1Cc2ccccc2C(C)(C)N1)c1ccccc1F
Structure:
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