Reaction Details Report a problem with these data
Target
Estrogen receptor beta
Ligand
BDBM50180512
Substrate
n/a
Meas. Tech.
ChEMBL_340344 (CHEMBL865583)
IC50
12±n/a nM
Citation
 Sun, W; Cama, LD; Birzin, ET; Warrier, S; Locco, L; Mosley, R; Hammond, ML; Rohrer, SP 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett 16:1468-72 (2006) [PubMed]  Article 
Target
Name:
Estrogen receptor beta
Synonyms:
Estrogen receptor | ER-beta | Estrogen receptor beta (ER beta) | Nuclear receptor subfamily 3 group A member 2 | estrogen beta | Estrogen receptor (ER beta) | Estrogen receptor beta (ER) | Estrogen receptor beta | ESR2_HUMAN | ESR2 | ESTRB | NR3A2 | Estradiol receptor beta (ERβ)
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Human
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM50180512
Synonyms:
1-methyl-5-vinyl-9,10-dihydrophenanthrene-2,7-diol | CHEMBL205119
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1c(O)ccc-2c1CCc1cc(O)cc(C=C)c-21
Structure:
Search PDB for entries with ligand similarity: