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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM7882
Substrate
n/a
Meas. Tech.
ChEMBL_2236133 (CHEMBL5149905)
IC50
352000±n/a nM
Citation
 Park, E; Song, KH; Kim, D; Lee, M; Van Manh, N; Kim, H; Hong, KB; Lee, J; Song, JY; Kang, S 2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRPĪ± Checkpoint. ACS Med Chem Lett 13:1459-1467 (2022) [PubMed] 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutamyl cyclase (QC) | Glutaminyl cyclase (QC) | Glutaminyl-tRNA cyclotransferase | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl Cyclase | QPCT_HUMAN | QPCT
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Human
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM7882
Synonyms:
CHEMBL540 | 1H-imidazole | imidazole | Imidazole (Im) | US9138393, Imidazole | US9144538, Imidazole
Type:
Small organic molecule
Emp. Form.:
C3H4N2
Mol. Mass.:
68.04
SMILES:
c1c[nH]cn1
Structure:
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