Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50601551
Substrate
n/a
Meas. Tech.
ChEMBL_2237594 (CHEMBL5151490)
Kd
0.100000±n/a nM
Citation
 Tropmann, K; Bresinsky, M; Forster, L; Mönnich, D; Buschauer, A; Wittmann, HJ; Hübner, H; Gmeiner, P; Pockes, S; Strasser, A Abolishing Dopamine D J Med Chem 64:8684-8709 (2021) [PubMed] 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
Cholinergic, muscarinic M2 | RecName: Full=Muscarinic acetylcholine receptor M2 | ACM2_HUMAN | CHRM2 | Muscarinic acetylcholine receptor M2 and M5 | Muscarinic acetylcholine receptor M2 and M4
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Human
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50601551
Synonyms:
CHEMBL5207281
Type:
Small organic molecule
Emp. Form.:
C16H25F6N7O5S
Mol. Mass.:
541.48
SMILES:
CCCCCNC(=O)N=C(/N)NCCCc1nnc(N)s1
Structure:
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