Reaction Details Report a problem with these data
Target
Thromboxane A2 receptor
Ligand
BDBM50184228
Substrate
n/a
Meas. Tech.
ChEMBL_364758
Ki
2.4±n/a nM
Citation
 Sturino, CF; Lachance, N; Boyd, M; Berthelette, C; Labelle, M; Li, L; Roy, B; Scheigetz, J; Tsou, N; Brideau, C; Cauchon, E; Carriere, MC; Denis, D; Greig, G; Kargman, S; Lamontagne, S; Mathieu, MC; Sawyer, N; Slipetz, D; O'Neill, G; Wang, Z; Zamboni, R; Metters, KM; Young, RN Identification of an indole series of prostaglandin D2 receptor antagonists. Bioorg Med Chem Lett 16:3043-8 (2006) [PubMed]  Article
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50184228
Synonyms:
2-(9-(4-chlorobenzyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid | CHEMBL206631
Type:
Small organic molecule
Emp. Form.:
C21H20ClNO2
Mol. Mass.:
353.842
SMILES:
OC(=O)CC1CCCc2c1n(Cc1ccc(Cl)cc1)c1ccccc21
Structure:
Search PDB for entries with ligand similarity: