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Target
Histamine H3 receptor
Ligand
BDBM50186277
Substrate
n/a
Meas. Tech.
ChEMBL_370711 (CHEMBL867234)
Ki
36.7±n/a nM
Citation
 Jesudason, CD; Beavers, LS; Cramer, JW; Dill, J; Finley, DR; Lindsley, CW; Stevens, FC; Gadski, RA; Oldham, SW; Pickard, RT; Siedem, CS; Sindelar, DK; Singh, A; Watson, BM; Hipskind, PA Synthesis and SAR of novel histamine H3 receptor antagonists. Bioorg Med Chem Lett 16:3415-8 (2006) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50186277
Synonyms:
1-(7-(3-(piperidin-1-yl)propoxy)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone | CHEMBL211290
Type:
Small organic molecule
Emp. Form.:
C19H28N2O2
Mol. Mass.:
316.4378
SMILES:
CC(=O)N1CCc2ccc(OCCCN3CCCCC3)cc2C1
Structure:
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