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Target
Histamine H3 receptor
Ligand
BDBM50186275
Substrate
n/a
Meas. Tech.
ChEMBL_370711 (CHEMBL867234)
Ki
38.1±n/a nM
Citation
 Jesudason, CD; Beavers, LS; Cramer, JW; Dill, J; Finley, DR; Lindsley, CW; Stevens, FC; Gadski, RA; Oldham, SW; Pickard, RT; Siedem, CS; Sindelar, DK; Singh, A; Watson, BM; Hipskind, PA Synthesis and SAR of novel histamine H3 receptor antagonists. Bioorg Med Chem Lett 16:3415-8 (2006) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50186275
Synonyms:
3-(methylsulfonyl)-7-(3-(piperidin-1-yl)propoxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine | CHEMBL209120
Type:
Small organic molecule
Emp. Form.:
C19H30N2O3S
Mol. Mass.:
366.518
SMILES:
CS(=O)(=O)N1CCc2ccc(OCCCN3CCCCC3)cc2CC1
Structure:
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