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Target
Integrase
Ligand
BDBM50187185
Substrate
n/a
Meas. Tech.
ChEMBL_383533 (CHEMBL867996)
IC50
150±n/a nM
Citation
 Fardis, M; Jin, H; Jabri, S; Cai, RZ; Mish, M; Tsiang, M; Kim, CU Effect of substitution on novel tricyclic HIV-1 integrase inhibitors. Bioorg Med Chem Lett 16:4031-5 (2006) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50187185
Synonyms:
7-(4-fluorobenzyl)-9-hydroxy-5-methoxy-6-methylene-6,7-dihydropyrrolo[3,4-g]quinolin-8-one | CHEMBL213852
Type:
Small organic molecule
Emp. Form.:
C20H15FN2O3
Mol. Mass.:
350.3431
SMILES:
COc1c2C(=C)N(Cc3ccc(F)cc3)C(=O)c2c(O)c2ncccc12
Structure:
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