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Target
Integrase
Ligand
BDBM50187198
Substrate
n/a
Meas. Tech.
ChEMBL_383533 (CHEMBL867996)
IC50
59±n/a nM
Citation
 Fardis, M; Jin, H; Jabri, S; Cai, RZ; Mish, M; Tsiang, M; Kim, CU Effect of substitution on novel tricyclic HIV-1 integrase inhibitors. Bioorg Med Chem Lett 16:4031-5 (2006) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50187198
Synonyms:
7-(4-fluorobenzyl)-9-hydroxy-5-methoxy-6-(3-oxo-3-(piperazin-1-yl)propylthio)-6,7-dihydropyrrolo[3,4-g]quinolin-8-one trifluoroacetic acid salt | CHEMBL385825
Type:
Small organic molecule
Emp. Form.:
C26H27FN4O4S
Mol. Mass.:
510.58
SMILES:
COc1c2C(SCCC(=O)N3CCNCC3)N(Cc3ccc(F)cc3)C(=O)c2c(O)c2ncccc12
Structure:
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