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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50192787
Substrate
n/a
Meas. Tech.
ChEMBL_422286 (CHEMBL906986)
IC50
53±n/a nM
Citation
 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors. Bioorg Med Chem Lett 16:5414-9 (2006) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11beta-HSD1A | 11-DH | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | 11-beta-HSD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 11-beta-hydroxysteroid dehydrogenase 1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | DHI1_MOUSE | Hsd11b1 | Hsd11
Type:
Enzyme
Mol. Mass.:
32369.70
Organism:
Mouse
Description:
P50172
Residue:
292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
  
Inhibitor
Name:
BDBM50192787
Synonyms:
N-[(1R,2S,5S,7S)-5-(5-amino-4H-[1,2,4]triazol-3-yl)-adamantan-2-yl]-2-(4-chloro-phenoxy)-2-methyl-propionamide | CHEMBL219136
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@@](c1nnc(N)[nH]1)(C2)C3
Structure:
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