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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50192788
Substrate
n/a
Meas. Tech.
ChEMBL_422284 (CHEMBL856010)
IC50
358±n/a nM
Citation
 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors. Bioorg Med Chem Lett 16:5414-9 (2006) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50192788
Synonyms:
2-(4-chloro-phenoxy)-2-methyl-N-[(1R,2S,5S,7S)-5-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-adamantan-2-yl]-propionamide | CHEMBL436335
Type:
Small organic molecule
Emp. Form.:
C22H26ClN3O4
Mol. Mass.:
431.913
SMILES:
CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nc(=O)o[nH]1 |wU:17.24,14.14,wD:19.19,21.27,TLB:13:14:22.17.18:20,THB:16:17:20:23.15.14,16:15:22.17.18:20,(25.58,-12.73,;24.26,-13.51,;22.93,-12.73,;25.58,-14.29,;26.93,-13.53,;28.25,-14.33,;29.59,-13.57,;29.61,-12.03,;30.95,-11.28,;28.27,-11.25,;26.94,-12.01,;22.92,-14.26,;22.9,-15.8,;21.59,-13.48,;20.31,-14.33,;20.3,-15.86,;19.28,-17.13,;17.88,-16.57,;17.87,-14.98,;18.91,-13.75,;17.56,-14.23,;17.57,-15.71,;16.38,-16.99,;18.9,-16.2,;16.23,-14.93,;14.82,-15.57,;13.78,-14.42,;12.25,-14.58,;14.56,-13.07,;16.07,-13.4,)|
Structure:
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