Target
Growth factor receptor-bound protein 2
Ligand
BDBM50193151
Substrate
n/a
Meas. Tech.
ChEMBL_422146 (CHEMBL863589)
Kd
1.8±n/a nM
Citation
 Choi, WJShi, ZDWorthy, KMBindu, LKarki, RGNicklaus, MCFisher, RJBurke, TR Application of azide-alkyne cycloaddition 'click chemistry' for the synthesis of Grb2 SH2 domain-binding macrocycles. Bioorg Med Chem Lett 16:5265-9 (2006) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50193151
Synonyms:
({4-[(5'S,11'S,24'S,30'S)-11',30'-bis(carbamoylmethyl)-3',6',9',12',22',25',28',31'-octaoxo-24'-{[4-(phosphonomethyl)phenyl]methyl}dispiro[cyclohexane-1,8'-[1,4,7,10,13,18,19,20,23,26,29,32,37,38]tetradecaazatricyclo[34.2.1.1^{17,20}]tetracontane-27',1''-cyclohexane]-17'(40'),18',36'(39'),37'-tetraen-5'-ylmethyl]phenyl}methyl)phosphonic acid | CHEMBL437910
Type:
Small organic molecule
Emp. Form.:
C56H78N16O16P2
Mol. Mass.:
1293.2636
SMILES:
NC(=O)C[C@@H]1NC(=O)C2(CCCCC2)NC(=O)[C@H](Cc2ccc(CP(O)(O)=O)cc2)NC(=O)Cn2cc(CCCNC(=O)[C@H](CC(N)=O)NC(=O)C3(CCCCC3)NC(=O)[C@H](Cc3ccc(CP(O)(O)=O)cc3)NC(=O)Cn3cc(CCCNC1=O)nn3)nn2
Structure:
Search PDB for entries with ligand similarity: