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Target
C-X-C chemokine receptor type 1
Ligand
BDBM50193979
Substrate
n/a
Meas. Tech.
ChEMBL_424262 (CHEMBL908414)
IC50
55±n/a nM
Citation
 Nie, H; Widdowson, KL; Palovich, MR; Fu, W; Elliott, JD; Bryan, DL; Burman, M; Schmidt, DB; Foley, JJ; Sarau, HM; Busch-Petersen, J N,N'-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors. Bioorg Med Chem Lett 16:5513-6 (2006) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM50193979
Synonyms:
3-{[[(2-bromophenyl)amino](cyanoimino)methyl]amino}-6-chloro-2-hydroxy-N,N-dimethylbenzenesulfonamide | CHEMBL218387
Type:
Small organic molecule
Emp. Form.:
C16H15BrClN5O3S
Mol. Mass.:
472.744
SMILES:
CN(C)S(=O)(=O)c1c(Cl)ccc(N=C(NC#N)Nc2ccccc2Br)c1O |w:12.11|
Structure:
Search PDB for entries with ligand similarity: