Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50195078
Substrate
n/a
Meas. Tech.
ChEMBL_424740 (CHEMBL907892)
EC50
1890±n/a nM
Citation
 Humphries, PS; Almaden, JV; Barnum, SJ; Carlson, TJ; Do, QQ; Fraser, JD; Hess, M; Kim, YH; Ogilvie, KM; Sun, S Pyridine-2-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents. Bioorg Med Chem Lett 16:6116-9 (2006) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50195078
Synonyms:
2-((5-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)pyrazin-2-yl)methyl)-tetrahydrofuran-2-carboxylic acid | CHEMBL221490
Type:
Small organic molecule
Emp. Form.:
C22H23N3O5
Mol. Mass.:
409.4351
SMILES:
Cc1oc(nc1CCOc1cnc(CC2(CCCO2)C(O)=O)cn1)-c1ccccc1
Structure:
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