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Target
D-3-phosphoglycerate dehydrogenase
Ligand
BDBM50232875
Substrate
n/a
Meas. Tech.
ChEMBL_2272272
Kd
5900000±n/a nM
Citation
 Zhao, JY; Feng, KR; Wang, F; Zhang, JW; Cheng, JF; Lin, GQ; Gao, D; Tian, P A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism. Eur J Med Chem 217:0 (2021) [PubMed] 
Target
Name:
D-3-phosphoglycerate dehydrogenase
Synonyms:
SERA_HUMAN | PHGDH | PGDH3 | D-3-phosphoglycerate dehydrogenase | Phosphoglycerate dehydrogenase (PHGDH)
Type:
Protein
Mol. Mass.:
56650.89
Organism:
Human
Description:
n/a
Residue:
533
Sequence:
MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTIQVITQGTSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGECLLAVALAGAPYQAVGLVQGTTPVLQGLNGAVFRPEVPLRRDLPLLLFRTQTSDPAMLPTMIGLLAEAGVRLLSYQTSLVSDGETWHVMGISSLLPSLEAWKQHVTEAFQFHF
  
Inhibitor
Name:
BDBM50232875
Synonyms:
CHEMBL1901807
Type:
Small organic molecule
Emp. Form.:
C8H6O3
Mol. Mass.:
150.03
SMILES:
Oc1ccc2C(=O)COc2c1
Structure:
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