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Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50195802
Substrate
n/a
Meas. Tech.
ChEMBL_421994 (CHEMBL907083)
IC50
330±n/a nM
Citation
 Wu, S; Fluxe, A; Sheffer, J; Janusz, JM; Blass, BE; White, R; Jackson, C; Hedges, R; Murawsky, M; Fang, B; Fadayel, GM; Hare, M; Djandjighian, L Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers. Bioorg Med Chem Lett 16:6213-8 (2006) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50195802
Synonyms:
1-(2,3-dimethylphenyl)-2-[2-(4-methoxyphenyl)ethyl]-2H-1,2,3,4,5-pentazol-1-ylium | CHEMBL387088
Type:
Small organic molecule
Emp. Form.:
C17H20N5O
Mol. Mass.:
310.3731
SMILES:
COc1ccc(CCn2nnn[n+]2-c2cccc(C)c2C)cc1
Structure:
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