Reaction Details Report a problem with these data
Target
Disintegrin and metalloproteinase domain-containing protein 17
Ligand
BDBM50195927
Substrate
n/a
Meas. Tech.
ChEMBL_452969 (CHEMBL902114)
IC50
>100000±n/a nM
Citation
 Duan, JJ; Chen, L; Lu, Z; Jiang, B; Asakawa, N; Sheppeck, JE; Liu, RQ; Covington, MB; Pitts, W; Kim, SH; Decicco, CP Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). Bioorg Med Chem Lett 17:266-71 (2006) [PubMed]  Article 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:
ADAM 17 | Snake venom-like protease | A disintegrin and metalloproteinase domain 17 | TNF-alpha-Converting Enzyme | ADA17_PIG | ADAM17 | TACE
Type:
Metalloprotease
Mol. Mass.:
12197.99
Organism:
Pig
Description:
Partially purified TACE was obtained from porcine spleen.
Residue:
112
Sequence:
MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
  
Inhibitor
Name:
BDBM50195927
Synonyms:
N-(5-methyl-2,4,6-trioxo-hexahydropyrimidin-5-yl)-4-((2-methylquinolin-4-yl)methoxy)benzamide | N-(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)-4-((2-methylquinolin-4-yl)methoxy)benzamide | CHEMBL391851
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1cc(COc2ccc(cc2)C(=O)NC2(C)C(=O)NC(=O)NC2=O)c2ccccc2n1
Structure:
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