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Target
Dual specificity protein kinase CLK2
Ligand
BDBM50585046
Substrate
n/a
Meas. Tech.
ChEMBL_2290894
IC50
2499±n/a nM
Citation
 Lindberg, MF; Deau, E; Arfwedson, J; George, N; George, P; Alfonso, P; Corrionero, A; Meijer, L Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases. J Med Chem 66:4106-4130 (2023) [PubMed] 
Target
Name:
Dual specificity protein kinase CLK2
Synonyms:
CDC-like kinase 2 (CLK2) | CDC2-like kinase 2 (CLK2) | 2.7.12.1 | CLK2_HUMAN | CDC-like kinase 2 | CLK2
Type:
n/a
Mol. Mass.:
60128.79
Organism:
Human
Description:
P49760
Residue:
499
Sequence:
MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR
  
Inhibitor
Name:
BDBM50585046
Synonyms:
CHEMBL5086263
Type:
Small organic molecule
Emp. Form.:
C22H18F4N8O
Mol. Mass.:
486.43
SMILES:
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2
Structure:
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