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Target
Dual specificity protein kinase CLK1
Ligand
BDBM50538084
Substrate
n/a
Meas. Tech.
ChEMBL_2290912
Kd
0.254000±n/a nM
Citation
 Lindberg, MF; Deau, E; Arfwedson, J; George, N; George, P; Alfonso, P; Corrionero, A; Meijer, L Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases. J Med Chem 66:4106-4130 (2023) [PubMed] 
Target
Name:
Dual specificity protein kinase CLK1
Synonyms:
CDC2-like kinase 1 (CLK1) | CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1 | CLK1_HUMAN | CLK1 | CLK
Type:
Protein
Mol. Mass.:
57322.21
Organism:
Human
Description:
P49759
Residue:
484
Sequence:
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
  
Inhibitor
Name:
BDBM50538084
Synonyms:
CHEMBL4647659
Type:
Small organic molecule
Emp. Form.:
C25H27FN6O4
Mol. Mass.:
494.53
SMILES:
CC(C)Oc1ccc(F)c(c1)-c1cnc(N)c(n1)C(=O)Nc1cnccc1N1CCC[C@H](C1)C(O)=O |r|
Structure:
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