Reaction Details Report a problem with these data
Target
Dual specificity protein kinase CLK1
Ligand
BDBM385170
Substrate
n/a
Meas. Tech.
ChEMBL_2290912
Kd
0.620000±n/a nM
Citation
 Lindberg, MF; Deau, E; Arfwedson, J; George, N; George, P; Alfonso, P; Corrionero, A; Meijer, L Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases. J Med Chem 66:4106-4130 (2023) [PubMed] 
Target
Name:
Dual specificity protein kinase CLK1
Synonyms:
CDC2-like kinase 1 (CLK1) | CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1 | CLK1_HUMAN | CLK1 | CLK
Type:
Protein
Mol. Mass.:
57322.21
Organism:
Human
Description:
P49759
Residue:
484
Sequence:
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
  
Inhibitor
Name:
BDBM385170
Synonyms:
US10287267, Compound 330 | US10556885, Compound 330 | US10508099, Compound 330 | US11174244, Compound 330 | US11673881, Compound 330
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCN(CC3)S(C)(=O)=O)cc2c1
Structure:
Search PDB for entries with ligand similarity: