Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 11
Ligand
BDBM50099349
Substrate
n/a
Meas. Tech.
ChEMBL_2293045
IC50
15±n/a nM
Citation
 Carlino, L; Rastelli, G Dual Kinase-Bromodomain Inhibitors in Anticancer Drug Discovery: A Structural and Pharmacological Perspective. J Med Chem 59:9305-9320 (2016) [PubMed] 
Target
Name:
Mitogen-activated protein kinase 11
Synonyms:
MAP kinase p38 | Mitogen-activated protein kinase p38 beta | Stress-activated protein kinase 2 | p38-2 | p38-beta | p38b | MK11_HUMAN | MAPK11 | PRKM11 | SAPK2 | SAPK2B | Mitogen-activated protein kinase 11 | p38 MAP kinase alpha/beta
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41351.73
Organism:
Human
Description:
gi_20128774
Residue:
364
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIEQ
  
Inhibitor
Name:
BDBM50099349
Synonyms:
2-(2,3-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-piperidin-4-yl-3H-imidazol-4-yl]-pyrimidine | CHEMBL14212
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1cccc(Oc2nccc(n2)-c2c(ncn2C2CCNCC2)-c2ccc(F)cc2)c1C
Structure:
Search PDB for entries with ligand similarity: