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Target
Heparanase
Ligand
BDBM50147534
Substrate
n/a
Meas. Tech.
ChEMBL_2296904
IC50
250±n/a nM
Citation
 Jia, L; Ma, S Recent advances in the discovery of heparanase inhibitors as anti-cancer agents. Eur J Med Chem 121:209-220 (2016) [PubMed] 
Target
Name:
Heparanase
Synonyms:
Heparanase-1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE1 | HSE1 | HPSE_HUMAN | HPSE
Type:
PROTEIN
Mol. Mass.:
61167.67
Organism:
Human
Description:
ChEMBL_327900
Residue:
543
Sequence:
MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
  
Inhibitor
Name:
BDBM50147534
Synonyms:
1,3-dioxo-2-(3-(5-phenylbenzo[d]oxazol-2-yl)-4-(propylamino)phenyl)isoindoline-5-carboxylic acid | 1,3-Dioxo-2-[3-(5-phenyl-benzooxazol-2-yl)-4-propylamino-phenyl]-indan-5-carboxylic acid | CHEMBL109657
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCCNc1ccc(cc1-c1nc2cc(ccc2o1)-c1ccccc1)N1C(=O)c2ccc(cc2C1=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: