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Target
rRNA adenine N-6-methyltransferase
Ligand
BDBM25400
Substrate
n/a
Meas. Tech.
ChEMBL_2299085
IC50
80000±n/a nM
Citation
 Jeremia, L; Deprez, BE; Dey, D; Conn, GL; Wuest, WM Ribosome-targeting antibiotics and resistance  RSC Med Chem 14:624-643 (2023) [PubMed] 
Target
Name:
rRNA adenine N-6-methyltransferase
Synonyms:
ERM_BACIU | Erythromycin resistance protein
Type:
PROTEIN
Mol. Mass.:
28925.75
Organism:
Bacillus subtilis
Description:
ChEMBL_67535
Residue:
244
Sequence:
MNEKNIKHSQNFITSKHNIDKIMTNIRLNEHDNIFEIGSGKGHFTLELVQRCNFVTAIEIDHKLCKTTENKLVDHDNFQVLNKDILQFKFPKNQSYKIFGNIPYNISTDIIRKIVFDSIADEIYLIVEYGFAKRLLNTKRSLALFLMAEVDISILSMVPREYFHPKPKVNSSLIRLNRKKSRISHKDKQKYNYFVMKWVNKEYKKIFTKNQFNNSLKHAGIDDLNNISFEQFLSLFNSYKLFNK
  
Inhibitor
Name:
BDBM25400
Synonyms:
cid_657378 | CPA | CHEMBL68738 | (2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol | N6-CyclopentylAdo | N6-cyclopentyladenosine (CPA)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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