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Target
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Ligand
BDBM50511422
Substrate
n/a
Meas. Tech.
ChEMBL_2299890
IC50
950±n/a nM
Citation
 Willems, HMG; Edwards, S; Boffey, HK; Chawner, SJ; Green, C; Romero, T; Winpenny, D; Skidmore, J; Clarke, JH; Andrews, SP Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor. RSC Med Chem 14:934-946 (2023) [PubMed] 
Target
Name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Synonyms:
1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha | 2.7.1.149 | Diphosphoinositide kinase 2-alpha | PI(5)P 4-kinase type II alpha | PIP4KII-alpha | PIP5KIII | Phosphatidylinositol 5-phosphate 4-kinase type II alpha | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | PtdIns(4)P-5-kinase B isoform | PtdIns(4)P-5-kinase C isoform | PtdIns(5)P-4-kinase isoform 2-alpha | PI42A_HUMAN | PIP4K2A | PI5P4KA | PIP5K2 | PIP5K2A | Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
Type:
PROTEIN
Mol. Mass.:
46228.59
Organism:
Human
Description:
ChEMBL_104274
Residue:
406
Sequence:
MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
  
Inhibitor
Name:
BDBM50511422
Synonyms:
CHEMBL4446338
Type:
Small organic molecule
Emp. Form.:
C31H29N7O2
Mol. Mass.:
531.62
SMILES:
CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2c[nH]c3ccccc23)c1
Structure:
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