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Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM50615240
Substrate
n/a
Meas. Tech.
ChEMBL_2300410
EC50
20400±n/a nM
Citation
 Li, P; Dorsch, W; Lauffer, DJ; Bilimoria, D; Chauret, N; Court, JJ; Das, SK; Denis, F; Mani, N; Nanthakumar, S; Nicolas, O; Rao, BG; Ronkin, S; Selliah, S; Shawgo, RS; Stearns, R; Tang, Q; Waal, ND; Green, J Discovery of Novel Allosteric HCV NS5B Inhibitors. 2. Lactam-Containing Thiophene Carboxylates. ACS Med Chem Lett 8:251-255 (2017) [PubMed] 
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1 | NR1I2_HUMAN | NR1I2 | PXR | Pregnane X receptor
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Human
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
  
Inhibitor
Name:
BDBM50615240
Synonyms:
CHEMBL5288911
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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