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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM80642
Substrate
n/a
Meas. Tech.
ChEMBL_2306822
IC50
109±n/a nM
Citation
 Bavo, F; Pallavicini, M; Pucci, S; Appiani, R; Giraudo, A; Oh, H; Kneisley, DL; Eaton, B; Lucero, L; Gotti, C; Clementi, F; Whiteaker, P; Bolchi, C Subnanomolar Affinity and Selective Antagonism at α7 Nicotinic Receptor by Combined Modifications of 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624). J Med Chem 66:306-332 (2023) [PubMed] 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_CHICK | CHRNA7
Type:
PROTEIN
Mol. Mass.:
56940.23
Organism:
Chicken
Description:
ChEMBL_120662
Residue:
502
Sequence:
MGLRALMLWLLAAAGLVRESLQGEFQRKLYKELLKNYNPLERPVANDSQPLTVYFTLSLMQIMDVDEKNQVLTTNIWLQMYWTDHYLQWNVSEYPGVKNVRFPDGLIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQKCNLKFGSWTYGGWSLDLQMQEADISGYISNGEWDLVGIPGKRTESFYECCKEPYPDITFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLSSMEMNTVSGQQCSNGNMLYIGFRGLDGVHCTPTTDSGVICGRMTCSPTEEENLLHSGHPSEGDPDLAKILEEVRYIANRFRDQDEEEAICNEWKFAASVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM80642
Synonyms:
CHEMBL191491 | cid_6433339 | MG 624 | MLS002172460 | SMR001254093 | triethyl-[2-[4-[(E)-2-phenylethenyl]phenoxy]ethyl]azanium;iodide | triethyl-[2-[4-[(E)-2-phenylethenyl]phenoxy]ethyl]ammonium;iodide | triethyl-[2-[4-[(E)-styryl]phenoxy]ethyl]ammonium;iodide
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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