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Target
Stimulator of interferon genes protein
Ligand
BDBM453551
Substrate
n/a
Meas. Tech.
ChEMBL_2310369
EC50
>100000±n/a nM
Citation
 Shan, B; Hou, H; Zhang, K; Li, R; Shen, C; Chen, Z; Xu, P; Cui, R; Su, Z; Zhang, C; Yang, R; Zhou, G; Liu, Y; Guo, H; Chen, K; Fu, W; Jiang, H; Zhang, S; Zheng, M Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists. J Med Chem 66:3327-3347 (2023) [PubMed] 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
Mediator of IRF3 activation | Transmembrane protein 173 | Endoplasmic reticulum interferon stimulator | Synonyms=ERIS | hSTING | hMITA | STING_HUMAN | STING1 | ERIS | MITA | STING | TMEM173
Type:
Protein
Mol. Mass.:
42215.19
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM453551
Synonyms:
4-(5,6-dimethoxybenzo[b]thiophen-2-yl)-4- oxobutanoic acid | US10730849, Example 16
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1cc2cc(sc2cc1OC)C(=O)CCC(=O)O
Structure:
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