Reaction Details
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Oxysterol-binding protein 2
Ligand
BDBM50617153
Substrate
n/a
Meas. Tech.
ChEMBL_2311003
Ki
2600±n/a nM
Citation
Severance, ZC; Nuñez, JI; Le-McClain, AT; Malinky, CA; Bensen, RC; Fogle, RS; Manginelli, GW; Sakers, SH; Falcon, EC; Bui, RH; Snead, KJ; Bourne, CR; Burgett, AWG Structure-Activity Relationships of Ligand Binding to Oxysterol-Binding Protein (OSBP) and OSBP-Related Protein 4. J Med Chem 66:3866-3875 (2023) [PubMed] More Info.:
Target
Name:
Oxysterol-binding protein 2
Synonyms:
OSBP2_HUMAN | OSBP2 | KIAA1664 | ORP4 | OSBPL4 | OSBP-related protein 4 (ORP4L)
Type:
Protein
Mol. Mass.:
101264.66
Organism:
Human
Description:
Q969R2
Residue:
916
Sequence:
MGKAAAPSRGGGCGGRSRGLSSLFTVVPCLSCHTAAPGMSASTSGSGPEPKPQPQPVPEPERGPLSEQVSEAVSEAVPRSEPVSETTSEPEPGAGQPSELLQGSRPGSESSSGVGAGPFTKAASEPLSRAVGSATFLRPESGSLPALKPLPLLRPGQAKTPLGVPMSGTGTTSSAPLALLPLDSFEGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTCRGTINLSTAHIDTEDSCGILLTSGARSYHLKASSEVDRQQWITALELAKAKAVRVMNTHSDDSGDDDEATTPADKSELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTELDGLKIPSESGEKLKVVNERATLFRITSNAMINACRDFLELAEIHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFHSAPGRPANPSKSFIEGSLLTPKGEDSEEDEDTEYFDAMEDSTSFITVITEAKEDSRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVKRRVRIPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNIF
Inhibitor
Name:
BDBM50617153
Synonyms:
SCHWEINFURTHIN A
Type:
Small organic molecule
Emp. Form.:
C34H44O6
Mol. Mass.:
548.72
SMILES:
[H][C@]12[#6]-c3cc(\[#6]=[#6]\c4cc(-[#8])c(-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c4)cc(-[#8])c3-[#8][C@]1([#6])[#6]-[#6@@H](-[#8])-[#6@@H](-[#8])C2([#6])[#6] |r|
Structure:
