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Target
Neurotensin receptor type 2
Ligand
BDBM50048908
Substrate
n/a
Meas. Tech.
ChEMBL_2317107
Kd
1.8±n/a nM
Citation
 Kühl, T; Georgieva, MG; Hübner, H; Lazarova, M; Vogel, M; Haas, B; Peeva, MI; Balacheva, AA; Bogdanov, IP; Milella, L; Ponticelli, M; Garev, T; Faraone, I; Detcheva, R; Minchev, B; Petkova-Kirova, P; Tancheva, L; Kalfin, R; Atanasov, AG; Antonov, L; Pajpanova, TI; Kirilov, K; Gastreich, M; Gmeiner, P; Imhof, D; Tzvetkov, NT Neurotensin(8-13) analogs as dual NTS1 and NTS2 receptor ligands with enhanced effects on a mouse model of Parkinson's disease. Eur J Med Chem 254:0 (2023) [PubMed] 
Target
Name:
Neurotensin receptor type 2
Synonyms:
Neurotensin receptor 2 | Levocabastine-sensitive neurotensin receptor | Neurotensin receptor type 2 | NTR2 receptor | NT-R-2 | NTR2 | NTR2_HUMAN | NTSR2 | Neurotensin receptor
Type:
PROTEIN
Mol. Mass.:
45404.76
Organism:
Human
Description:
ChEMBL_1281495
Residue:
410
Sequence:
METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT
  
Inhibitor
Name:
BDBM50048908
Synonyms:
CHEMBL415788
Type:
Small organic molecule
Emp. Form.:
C38H64N12O8
Mol. Mass.:
816.50
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(O)=O |r|
Structure:
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