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Target
Non-receptor tyrosine-protein kinase TYK2 [5-1181]
Ligand
BDBM424454
Substrate
n/a
Meas. Tech.
ChEMBL_2317937
Kd
0.067000±n/a nM
Citation
 Leit, S; Greenwood, J; Carriero, S; Mondal, S; Abel, R; Ashwell, M; Blanchette, H; Boyles, NA; Cartwright, M; Collis, A; Feng, S; Ghanakota, P; Harriman, GC; Hosagrahara, V; Kaila, N; Kapeller, R; Rafi, SB; Romero, DL; Tarantino, PM; Timaniya, J; Toms, AV; Wester, RT; Westlin, W; Srivastava, B; Miao, W; Tummino, P; McElwee, JJ; Edmondson, SD; Masse, CE Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279. J Med Chem 66:10473-10496 (2023) [PubMed] 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [5-1181]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 | TYK2_MOUSE | Tyk2
Type:
PROTEIN
Mol. Mass.:
132654.63
Organism:
Mouse
Description:
ChEMBL_105608
Residue:
1177
Sequence:
MPLCGRRAILEDSKADGTEAQPLVPTGCLMVLLHWPGPEGGEPWVTFSQTSLTAEEVCIHIAHKVGITPPCLNLFALYNAQAKVWLPPNHILDTSQDMNLYFRMRFYFRNWHGMNPQEPAVYRCGFPGAETSSDRAEQGVQLLDSASFEYLFEQGKHEFMNDVVSLRDLSSEEEIHHFKNESLGMAFLHLCHLALSRGVPLEEMAREISFKNCIPHSFRQHIRQHNVLTRLRLHRVFRRFLRAFRPGHLSQQVVMVKYLATLERLAPRFGSERIPVCHLEVLAQPERDPCYIQNSGQTAGDPGPELPSGPPTHEVLVTGTGGIQWHPLQTQESERGNSRGNPHGSRSGKKPKAPKAGEHLTESPQEPPWTYFCDFQDISHVVLKERRVHIHLQDNKCLLLCLCSQAEALSFVALVDGYFRLTADSSHYLCHEVAPPRLVTSIQNGIHGPLMDPFVQAKLWPEDGLYLIQWSTSHLHRLILTVAHRNPAFSNGPRGLRLRKFPITQQPGAFVLDGWGRSFASLGDLRLALQGCSLRAGDDCFPLHHCCLPRPREISNLVIMRGSRAHTRPLNLSQLSFHRVHQDEITQLSHLGQGTRTNVYEGLLRVGGPDEGKVDNGCPPEPGGTSGQQLRVVLKVLDPSHHDIALAFYETASLMSQVSHMHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLRRQRGQVPMTWKMVVAQQLASALSYLEDKNLVHGNVCGRNILLARLGLEEGTNPFIKLSDPGVGQGALSREERVERIPWTAPECLSGGTSSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEPSSPELATLTRQCLTYEPAQRPSFRTILRDLTRLQPQNLVGTSAVNSDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHMKFTELIGHTQGQMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQTAQEKYQGQVPSVF
  
Inhibitor
Name:
BDBM424454
Synonyms:
US10508120, Compound I-1183 | US10508120, Compound I-909 | US10577373, Compound I-1183 | US11046698, Compound I-1183 | US11414431, Compound I-263
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CNc1cc(Nc2cccn(-c3ccccn3)c2=O)nc2c(cnn12)C(=O)N[C@H]1CC[C@@H]1OC |r|
Structure:
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