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Target
17-beta-hydroxysteroid dehydrogenase type 2
Ligand
BDBM50266402
Substrate
n/a
Meas. Tech.
ChEMBL_2324328
IC50
36±n/a nM
Citation
 Salah, M; Tahoun, M; Rudzitis-Auth, J; Stotz, L; van Koppen, CJ; Laschke, MW; Abdelsamie, AS; Frotscher, M Potent Dual Inhibitors of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for  J Med Chem 66:8975-8992 (2023) [PubMed] 
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 2
Synonyms:
20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | Testosterone 17-beta-dehydrogenase | Estradiol 17-beta-dehydrogenase 2 (17beta-HSD2) | Microsomal 17-beta-hydroxysteroid dehydrogenas | 17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) | DHB2_HUMAN | HSD17B2 | EDH17B2 | SDR9C2 | Estradiol 17-beta-dehydrogenase 2
Type:
Oxidoreductase; single-pass type II membrane protein
Mol. Mass.:
42795.29
Organism:
Human
Description:
Enzyme was partially purified from human placenta.
Residue:
387
Sequence:
MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYDYFAKRHFGQDKPMPRALRMPNYKKKAT
  
Inhibitor
Name:
BDBM50266402
Synonyms:
CHEMBL4071245
Type:
Small organic molecule
Emp. Form.:
C17H10ClF2NO5S2
Mol. Mass.:
445.85
SMILES:
NS(=O)(=O)Oc1ccc(cc1Cl)-c1ccc(s1)C(=O)c1c(F)ccc(O)c1F
Structure:
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