Target
Microtubule-associated protein tau
Ligand
BDBM50030282
Substrate
n/a
Meas. Tech.
ChEMBL_2325681
IC50
10900±n/a nM
Citation
 Tonelli, MCatto, MSabaté, RFrancesconi, VLaurini, EPricl, SPisani, LMiniero, DVLiuzzi, GMGatta, ERelini, AGavín, RDel Rio, JASparatore, FCarotti, A Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease. Eur J Med Chem 250:0 (2023) [PubMed] 
Target
Name:
Microtubule-associated protein tau
Synonyms:
Tau Protein | Neurofibrillary tangle protein | PHF-tau | Microtubule-associated protein tau | Paired helical filament-tau | TAU_HUMAN | MAPT | MAPTL | MTBT1 | TAU
Type:
Protein
Mol. Mass.:
78928.63
Organism:
Human
Description:
P10636
Residue:
758
Sequence:
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
  
Inhibitor
Name:
BDBM50030282
Synonyms:
CHEBI:51052 | Lucanthone
Type:
Small organic molecule
Emp. Form.:
C20H24N2OS
Mol. Mass.:
340.49
SMILES:
CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12
Structure:
Search PDB for entries with ligand similarity: