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Target
Amyloid-beta precursor protein
Ligand
BDBM50030282
Substrate
n/a
Meas. Tech.
ChEMBL_2325682
IC50
24000±n/a nM
Citation
 Tonelli, M; Catto, M; Sabaté, R; Francesconi, V; Laurini, E; Pricl, S; Pisani, L; Miniero, DV; Liuzzi, GM; Gatta, E; Relini, A; Gavín, R; Del Rio, JA; Sparatore, F; Carotti, A Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease. Eur J Med Chem 250:0 (2023) [PubMed] 
Target
Name:
Amyloid-beta precursor protein
Synonyms:
A4_HUMAN | APP | A4 | AD1 | Cerebral vascular amyloid peptide | Amyloid intracellular domain 59 | P3(42) | PN-II | AICD-50 | PreA4 | Amyloid intracellular domain 57 | S-APP-alpha | P3(40) | Amyloid beta Protein | Gamma Secretase | S-APP-beta | Soluble APP-beta | Alzheimer disease amyloid protein | Gamma-CTF(59) | Gamma-CTF(57) | Protease nexin-II | Amyloid intracellular domain 50 | Beta amyloid A4 protein | C31 | AID(59) | Gamma-CTF(50) | C99 | AID(57) | Amyloid beta A4 protein | Gamma-secretase C-terminal fragment 50 | Amyloid beta protein (sAPPbeta) | Beta-amyloid protein 42 | Gamma-secretase C-terminal fragment 57 | Gamma-secretase C-terminal fragment 59 | Beta-amyloid protein 40 | Soluble APP-alpha | AICD-57 | Gamma-secretase | Amyloid -protein (A 42) | Amyloid protein (Abeta42b) | Beta-APP42 | APPI | Beta-APP40 | Amyloid beta protein Abeta(1-42) | beta-Amyloid Precursor Protein (APP) | AID(50) | CVAP | AICD-59 | ABPP | C83
Type:
Single-pass type I membrane protein
Mol. Mass.:
86890.41
Organism:
Human
Description:
P05067
Residue:
770
Sequence:
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
  
Inhibitor
Name:
BDBM50030282
Synonyms:
CHEBI:51052 | Lucanthone
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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