Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50108877
Substrate
n/a
Meas. Tech.
ChEMBL_2326426
Kd
440±n/a nM
Citation
 Pinheiro, F; Varejão, N; Sánchez-Morales, A; Bezerra, F; Navarro, S; Velázquez-Campoy, A; Busqué, F; Almeida, MR; Alibés, R; Reverter, D; Pallarès, I; Ventura, S PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties. Eur J Med Chem 261:0 (2023) [PubMed] 
Target
Name:
Transthyretin
Synonyms:
Transthyretin (TTR) | ATTR | Prealbumin | TBPA | TTHY_HUMAN | TTR | PALB
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Human
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50108877
Synonyms:
CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-5-nitrophenyl)(p-tolyl)methanone | Talcapone | (3,4-Dihydroxy-5-nitro-phenyl)-p-tolyl-methanone | TOLCAPONE
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1ccc(cc1)C(=O)c2cc(c(c(c2)O)O)[N+](=O)[O-]
Structure:
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