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Target
Forkhead box protein O3
Ligand
BDBM50462013
Substrate
n/a
Meas. Tech.
ChEMBL_2335676
EC50
37700±n/a nM
Citation
 Dotou, M; L'honoré, A; Moumné, R; El Amri, C Amide Alkaloids as Privileged Sources of Senomodulators for Therapeutic Purposes in Age-Related Diseases. J Nat Prod 87:617-628 (2024) [PubMed] 
Target
Name:
Forkhead box protein O3
Synonyms:
AF6q21 protein | FKHRL1 | Forkhead box protein O3 | Forkhead in rhabdomyosarcoma-like 1 | FOXO3_HUMAN | FOXO3 | FKHRL1 | FOXO3A
Type:
PROTEIN
Mol. Mass.:
71261.26
Organism:
Human
Description:
ChEMBL_101326
Residue:
673
Sequence:
MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLPVMGHEKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG
  
Inhibitor
Name:
BDBM50462013
Synonyms:
CHEBI:8241 | Piplartine
Type:
Small organic molecule
Emp. Form.:
C17H19NO5
Mol. Mass.:
317.34
SMILES:
COc1cc(cc(c1OC)OC)/C=C/C(=O)N2CCC=CC2=O
Structure:
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