Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 4
Ligand
BDBM50209260
Substrate
n/a
Meas. Tech.
ChEMBL_455257 (CHEMBL906418)
Ki
100±n/a nM
Citation
 Burdi, DF; Chi, S; Mattia, K; Harrington, C; Shi, Z; Chen, S; Jacutin-Porte, S; Bennett, R; Carson, K; Yin, W; Kansra, V; Gonzalo, JA; Coyle, A; Jaffee, B; Ocain, T; Hodge, M; LaRosa, G; Harriman, G Small molecule antagonists of the CC chemokine receptor 4 (CCR4). Bioorg Med Chem Lett 17:3141-5 (2007) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 4
Synonyms:
C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5
Type:
Enzyme
Mol. Mass.:
41406.41
Organism:
Homo sapiens (Human)
Description:
P51679
Residue:
360
Sequence:
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
  
Inhibitor
Name:
BDBM50209260
Synonyms:
(S)-1-(5-chloronaphthalen-2-ylsulfonyl)-N-methyl-N-(1-phenethylpiperidin-4-yl)pyrrolidine-2-carboxamide | CHEMBL246334
Type:
Small organic molecule
Emp. Form.:
C29H34ClN3O3S
Mol. Mass.:
540.117
SMILES:
CN(C1CCN(CCc2ccccc2)CC1)C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1
Structure:
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