Reaction Details Report a problem with these data
Target
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Ligand
BDBM50625383
Substrate
n/a
Meas. Tech.
ChEMBL_2345394
Kd
670±n/a nM
Citation
 Ji, W; Wang, ES; Manz, TD; Jiang, J; Donovan, KA; Abulaiti, X; Fischer, ES; Cantley, LC; Zhang, T; Gray, NS Development of potent and selective degraders of PI5P4Kγ. Eur J Med Chem 247:0 (2023) [PubMed] 
Target
Name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Synonyms:
Phosphatidylinositol-5-phosphate 4-kinase type II gamma | PIP4KII-gamma | PI(5)P 4-kinase type II gamma | PI42C_HUMAN | PIP4K2C | PIP5K2C | Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma
Type:
PROTEIN
Mol. Mass.:
47302.35
Organism:
Human
Description:
ChEMBL_774614
Residue:
421
Sequence:
MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIFA
  
Inhibitor
Name:
BDBM50625383
Synonyms:
CHEMBL5440896
Type:
Small organic molecule
Emp. Form.:
C42H42N8O7
Mol. Mass.:
770.85
SMILES:
O=C(CCCCCCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)Nc1cccc(Nc2cc(ncn2)-c2c[nH]c3ccccc23)c1
Structure:
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