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Target
Lysophosphatidic acid receptor 1
Ligand
BDBM50211655
Substrate
n/a
Meas. Tech.
ChEMBL_455637
IC50
140±n/a nM
Citation
 Yamamoto, T; Fujita, K; Asari, S; Chiba, A; Kataba, Y; Ohsumi, K; Ohmuta, N; Iida, Y; Ijichi, C; Iwayama, S; Fukuchi, N; Shoji, M Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists. Bioorg Med Chem Lett 17:3736-40 (2007) [PubMed]  Article  BDB Entry
Target
Name:
Lysophosphatidic acid receptor 1
Synonyms:
LPA receptor 1 | LPA-1 | LPAR1 | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2
Type:
Enzyme
Mol. Mass.:
41120.55
Organism:
Homo sapiens (Human)
Description:
Q92633
Residue:
364
Sequence:
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
  
Inhibitor
Name:
BDBM50211655
Synonyms:
4-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl)isoxazol-3-yl)phenylamino)-4-oxobutanoic acid | CHEMBL246735
Type:
Small organic molecule
Emp. Form.:
C22H20ClN3O6
Mol. Mass.:
457.864
SMILES:
CC(OC(=O)Nc1conc1-c1ccc(NC(=O)CCC(O)=O)cc1)c1ccccc1Cl
Structure:
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