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Target
Oxysterol-binding protein 1
Ligand
BDBM50630084
Substrate
n/a
Meas. Tech.
ChEMBL_2361584
Ki
119±n/a nM
Citation
 Jézéquel, G; Rampal, C; Guimard, C; Kovacs, D; Polidori, J; Bigay, J; Bignon, J; Askenatzis, L; Litaudon, M; Pham, VC; Huong, DTM; Nguyen, AL; Pruvost, A; Virolle, T; Mesmin, B; Desrat, S; Antonny, B; Roussi, F Structure-Based Design of a Lead Compound Derived from Natural Schweinfurthins with Antitumor Properties That Target Oxysterol-Binding Protein. J Med Chem 66:14208-14220 (2023) [PubMed] 
Target
Name:
Oxysterol-binding protein 1
Synonyms:
OSBP | OSBP1 | Oxysterol-binding protein 1
Type:
PROTEIN
Mol. Mass.:
89428.62
Organism:
Homo sapiens
Description:
ChEMBL_118953
Residue:
807
Sequence:
MAATELRGVVGPGPAAIAALGGGGAGPPVVGGGGGRGDAGPGSGAASGTVVAAAAGGPGPGAGGVAAAGPAPAPPTGGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHIYRGEYWECKEKQDWSSCPDIF
  
Inhibitor
Name:
BDBM50630084
Synonyms:
CHEMBL5394654
Type:
Small organic molecule
Emp. Form.:
C32H40O5
Mol. Mass.:
504.67
SMILES:
[H][C@]12[#6]-c3cc(\[#6]=[#6]\c4cc(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c4)c(-[#6]-[#6]=[#6])c(-[#8])c3-[#8][C@]1([#6])[#6]-[#6]-[#6@@H](-[#8])C2([#6])[#6] |r|
Structure:
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