Target
Motilin receptor
Ligand
BDBM50214264
Substrate
n/a
Meas. Tech.
ChEMBL_447563
IC50
28±n/a nM
Citation
 Marsault, EBenakli, KBeaubien, SSaint-Louis, CDéziel, RFraser, G Potent macrocyclic antagonists to the motilin receptor presenting novel unnatural amino acids. Bioorg Med Chem Lett 17:4187-90 (2007) [PubMed]  Article  BDB Entry
Target
Name:
Motilin receptor
Synonyms:
G-protein coupled receptor 38
Type:
PROTEIN
Mol. Mass.:
45365.95
Organism:
Homo sapiens (Human)
Description:
ChEMBL_122664
Residue:
412
Sequence:
MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
  
Inhibitor
Name:
BDBM50214264
Synonyms:
1-{[(5R,8R,11S)-6,9,12-trioxo-8-(propan-2-yl)-5-{[3-(trifluoromethyl)phenyl]methyl}-3,4,5,6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-2H-1,4,7,10,13-benzoxatetrazacyclooctadecin-11-yl]methyl}guanidine | CHEMBL396413
Type:
Small organic molecule
Emp. Form.:
C30H40F3N7O4
Mol. Mass.:
619.6783
SMILES:
[#6]-[#6](-[#6])-[#6@H]-1-[#7]-[#6](=O)-[#6@@H](-[#6]-c2cccc(c2)C(F)(F)F)-[#7]-[#6]-[#6]-[#8]-c2ccccc2-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6]-1=O
Structure:
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