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Target
Beta-3 adrenergic receptor
Ligand
BDBM50218167
Substrate
n/a
Meas. Tech.
ChEMBL_457025 (CHEMBL671849)
EC50
57±n/a nM
Citation
 Lafontaine, JA; Day, RF; Dibrino, J; Hadcock, JR; Hargrove, DM; Linhares, M; Martin, KA; Maurer, TS; Nardone, NA; Tess, DA; Dasilva-Jardine, P Discovery of potent and orally bioavailable heterocycle-based beta3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity. Bioorg Med Chem Lett 17:5245-50 (2007) [PubMed]  Article  BDB Entry
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50218167
Synonyms:
(R)-2-(2-(4-(2-isopropyloxazol-4-yl)phenoxy)ethylamino)-1-(pyridin-3-yl)ethanol | CHEMBL250352
Type:
Small organic molecule
Emp. Form.:
C21H25N3O3
Mol. Mass.:
367.4415
SMILES:
CC(C)c1nc(co1)-c1ccc(OCCNC[C@H](O)c2cccnc2)cc1
Structure:
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