Reaction Details Report a problem with these data
Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM50085415
Substrate
n/a
Meas. Tech.
ChEMBL_2422792
Kd
468±n/a nM
Citation
 Zhu, Z; Li, J; Shen, S; Al-Furas, H; Li, S; Tong, Y; Li, Y; Zeng, Y; Feng, Q; Chen, K; Ma, N; Zhou, F; Zhang, Z; Li, Z; Pang, J; Ding, K; Xu, F Targeting EGFR degradation by autophagosome degraders. Eur J Med Chem 270:0[PubMed] 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B light chain 3 B | Microtubule-associated protein 1 light chain 3 beta | MAP1A/MAP1B LC3 B | MLP3B_HUMAN | MAP1LC3B | MAP1ALC3
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM50085415
Synonyms:
G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one | 3-[1-(3,5-Dibromo-4-hydroxy-phenyl)-meth-(Z)-ylidene]-5-iodo-1,3-dihydro-indol-2-one | GW-5074 | CHEMBL72365 | 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Oc1c(Br)cc(\C=C2/C(=O)Nc3ccc(I)cc23)cc1Br
Structure:
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