Target
D(3) dopamine receptor
Ligand
BDBM50219945
Substrate
n/a
Meas. Tech.
ChEMBL_449063 (CHEMBL898268)
IC50
0.7±n/a nM
Citation
 Agai-Csongor, ENógrádi, KGalambos, JVágó, IBielik, AMagdó, IIgnácz-Szendrei, GKeseru, GMGreiner, ILaszlovszky, ISchmidt, EKiss, BSághy, KLaszy, JGyertyán, IZájer-Balázs, MGémesi, LDomány, G Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. Bioorg Med Chem Lett 17:5340-4 (2007) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50219945
Synonyms:
CHEMBL240273 | N-((1r,4r)-4-(2-(4-(3-cyano-5-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)cyclohexyl)-2-oxo-1,2,3,4-tetrahydroquinoline-6-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C29H34F3N5O3S
Mol. Mass.:
589.672
SMILES:
FC(F)(F)c1cc(cc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2ccc3NC(=O)CCc3c2)CC1)C#N |wU:19.23,wD:16.16,(25.61,-7.7,;24.27,-6.93,;23.5,-8.26,;25.05,-5.6,;22.95,-6.16,;22.95,-4.61,;21.6,-3.84,;20.28,-4.61,;20.29,-6.15,;21.6,-6.92,;18.95,-6.91,;18.94,-8.45,;17.61,-9.21,;16.28,-8.44,;14.94,-9.21,;13.61,-8.44,;12.28,-9.21,;10.94,-8.44,;9.61,-9.21,;9.61,-10.76,;10.94,-11.53,;12.28,-10.76,;8.26,-11.55,;6.9,-10.78,;6.14,-12.13,;7.66,-9.44,;5.57,-10.01,;4.24,-10.78,;2.9,-10.01,;2.9,-8.47,;1.57,-7.72,;1.56,-6.17,;.22,-5.4,;2.89,-5.4,;4.23,-6.17,;4.24,-7.7,;5.58,-8.47,;16.28,-6.9,;17.61,-6.14,;21.6,-2.3,;21.6,-.77,)|
Structure:
Search PDB for entries with ligand similarity: