Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM361577
Substrate
n/a
Meas. Tech.
ChEMBL_2431333
IC50
57±n/a nM
Citation
 Guo, Y; Xue, H; Hu, N; Liu, Y; Sun, H; Yu, D; Qin, L; Shi, G; Wang, F; Xin, L; Sun, W; Zhang, F; Song, X; Li, S; Wei, Q; Guo, Y; Li, Y; Liu, X; Chen, S; Zhang, T; Wu, Y; Su, D; Zhu, Y; Xu, A; Xu, H; Yang, S; Zheng, Z; Liu, J; Yang, X; Yuan, X; Hong, Y; Sun, X; Guo, Y; Zhou, C; Liu, X; Wang, L; Wang, Z Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2. J Med Chem 67:7836-7858[PubMed] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | Bcl-2 Protein | BCL2_HUMAN | BCL2
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Human
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM361577
Synonyms:
(S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitrophenyl)sulfonyl)-2-((1H-pyrrolo[2,3-b]pyridin- 5-yl)oxy)-4-(4-((6-(4-chlorophenyl)spiro[3.5]non-6- en-7-yl)methyl)piperazin-1-yl)benzamide | US10221174, Compound 6 | US10829488, Compound 6 | US11718613, Compound 6
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
[O-][N+](=O)c1cc(ccc1NC[C@H]1COCCO1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC3(CCC3)CC2)c2ccc(Cl)cc2)CC1 |r,t:49|
Structure:
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