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Target
Glutamate receptor ionotropic, NMDA 2B
Ligand
BDBM50220731
Substrate
n/a
Meas. Tech.
ChEMBL_449356 (CHEMBL899623)
IC50
>1000±n/a nM
Citation
 Kawai, M; Nakamura, H; Sakurada, I; Shimokawa, H; Tanaka, H; Matsumizu, M; Ando, K; Hattori, K; Ohta, A; Nukui, S; Omura, A; Kawamura, M Discovery of novel and orally active NR2B-selective N-methyl-D-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity. Bioorg Med Chem Lett 17:5533-6 (2007) [PubMed]  Article 
Target
Name:
Glutamate receptor ionotropic, NMDA 2B
Synonyms:
GluN2B | Glutamate [NMDA] receptor subunit epsilon 2 | Grin2b | N-methyl D-aspartate receptor subtype 2B | NMDA receptor subunit N2B (GluN2B) | NMDAR2B | NMDE2_RAT | NR2B
Type:
Protein
Mol. Mass.:
166077.66
Organism:
Rattus norvegicus (Rat)
Description:
Q00960
Residue:
1482
Sequence:
MKPSAECCSPKFWLVLAVLAVSGSKARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSTSSIDGLYDCDNPPFTTQPRSISKKPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHLKHGTGEKHGVVGGVPAPWEKNLTNVDWEDRSGGNFCRSCPSKLHNYSSTVAGQNSGRQACIRCEACKKAGNLYDISEDNSLQELDQPAAPVAVTSNASSTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPRSVSLKDKGRFMDGSPYAHMFEMPAGESSFANKSSVPTAGHHHNNPGSGYMLSKSLYPDRVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKTRPDFRALVTNKPVVVTLHGAVPGRFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV
  
Inhibitor
Name:
BDBM50220731
Synonyms:
CHEMBL393609 | N-((1r,4r)-4-(4-hydroxyphenyl)cyclohexyl)-3-(1-methyl-1H-benzo[d]imidazol-2-yl)propanamide
Type:
Small organic molecule
Emp. Form.:
C23H27N3O2
Mol. Mass.:
377.4794
SMILES:
Cn1c(CCC(=O)N[C@H]2CC[C@@H](CC2)c2ccc(O)cc2)nc2ccccc12 |wU:11.14,wD:8.7,(27.83,-9.24,;27.07,-7.91,;25.61,-7.43,;24.27,-8.19,;22.94,-7.41,;21.6,-8.17,;21.6,-9.72,;20.26,-7.4,;18.93,-8.17,;17.58,-7.38,;16.25,-8.17,;16.25,-9.71,;17.58,-10.48,;18.93,-9.71,;14.92,-10.49,;13.58,-9.71,;12.24,-10.49,;12.24,-12.04,;10.91,-12.81,;13.59,-12.8,;14.93,-12.03,;25.61,-5.89,;27.08,-5.42,;27.84,-3.92,;29.37,-3.9,;30.15,-5.23,;29.39,-6.56,;27.85,-6.57,)|
Structure:
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