Reaction Details Report a problem with these data
Target
Vasopressin V2 receptor
Ligand
BDBM50222059
Substrate
n/a
Meas. Tech.
ChEMBL_449800 (CHEMBL898895)
IC50
11±n/a nM
Citation
Molinari, AJ; Trybulski, EJ; Bagli, J; Croce, S; Considine, J; Qi, J; Ali, K; Demaio, W; Lihotz, L; Cochran, D Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan. Bioorg Med Chem Lett 17:5796-800 (2007) [PubMed] Article
More Info.:
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Human
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
Inhibitor
Name:
BDBM50222059
Synonyms:
CHEMBL392363 | N-[3-chloro-4-(3-oxo-2,3-dihydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyl)-phenyl]-5-fluoro-2-methyl-benzamide
Type:
Small organic molecule
Emp. Form.:
C27H21ClFN3O3
Mol. Mass.:
489.925
SMILES:
Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2C=C3CCC(=O)N3Cc3ccccc23)c(Cl)c1 |t:19|